Introduction

Are you struggling with weight loss and looking for effective solutions? 

Look no further! In this article, we will explore three medications that have shown promising results in weight loss management programs: Semaglutide, Terzepatide, and Naltrexone. We will delve into their unique characteristics, mechanisms of action, and how they can help you on your weight loss journey.

SEMAGLUTIDE – The GLP-1 Agonist for Successful Weight Loss 

Semaglutide, a member of the glucagon-like peptide-1 receptor agonists (GLP-1 agonists) class, has emerged as a game-changer in weight loss management. By mimicking the action of the hormone GLP-1, it effectively regulates blood sugar levels and reduces appetite. 

Clinical trials have demonstrated significant weight loss benefits with semaglutide, making it a highly sought-after medication since it has been approved by FDA . 

There are currently three FDA-approved semaglutide products: Ozempic injection and Rybelsus tablets are approved to lower blood sugar levels in adults with type 2 diabetes mellitus, in addition to diet and exercise. – (FDA)

Here at Transcend Rejuvenation, we offer free virtual consultations to help you understand more about semaglutide and its potential role in your weight loss journey.

 

TERZEPATIDE – The Innovative Dual Agonist

Terzepatide, an investigational medication that’s on late-stage FDA approval  (LINK), combines the actions of GLP-1 agonists and glucose-dependent insulinotropic polypeptide receptor agonists (GIP agonists). 

This unique combination offers a novel approach to weight loss and holds promise for individuals struggling with obesity and type 2 diabetes. Terzepatide, though still in the experimental stage, has demonstrated impressive efficacy in clinical trials. 

Stay informed about the latest developments in Terzepatide’s approval and availability through Transcend Rejuvenation’s free virtual consultations.

 

Naltrexone/Bupropion – The Dynamic Duo for Chronic Weight Management 

Naltrexone/bupropion (Contrave) is a medication that combines an opioid receptor antagonist (naltrexone) with a dopamine and norepinephrine reuptake inhibitor (bupropion). 

It is used as an adjunct to increased physical activity and a reduced-calorie diet for chronic weight management in adults with a body mass index (BMI) of at least 30 kg per m2 or a BMI of at least 27 kg per m2 with weight-related comorbidities such as type 2 diabetes mellitus, hyperlipidemia, or hypertension.

Naltrexone/bupropion has been evaluated in several studies and has shown greater weight loss compared to placebo when combined with a diet and exercise program.

It has been found to be effective in achieving clinically significant weight loss, with about four patients needing to be treated with naltrexone/bupropion instead of placebo for one additional patient to achieve at least a 5% weight loss.

It is important to note that naltrexone/bupropion may have safety concerns, such as the risk of depression, hypertension, seizures, acute opioid withdrawal, and opioid overuse. 

However, clinical trials of the combination therapy have not shown an increase in depression or suicidality compared to placebo.

To determine if naltrexone/bupropion is suitable for you, consult with our experts at Transcend Rejuvenation through our free virtual consultations. 

We will provide personalized guidance and support throughout your weight loss journey, regardless 

Weight loss can be a challenging journey, but with the right support and medication, success is within reach. 

Semaglutide, Terzepatide, and Naltrexone/bupropion offer unique approaches to weight loss management.

Take the first step towards a healthier you today by calling 385-249-5785!

 

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8314402/

https://www.aafp.org/pubs/afp/issues/2015/0415/p554.html

https://www.everydayhealth.com/weight/type-2-diabetes-drug-mounjaro-leads-to-weight-loss-in-new-trial-for-treatment-of-overweight-or-obesity/

https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medications-containing-semaglutide-marketed-type-2-diabetes-or-weight-loss#:~:text=Wegovy%20injection%20is%20approved%20to,addition%20to%20diet%20and%20exercise.